|
KMID : 0352720200440030496
|
|
Journal of Ginseng Research
2020 Volume.44 No. 3 p.496 ~ p.505
|
|
|
Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B?irradiated hairless mice
|
|
Saba Evelyn
Kim Seung-Hyung
Lee Yuan-Yee
Park Chae-Kyu
Oh Jae-Wook
Kim Tae-Hwan
Kim Hyun-Kyoung
Roh Seong-Soo
Rhee Man-Hee
|
|
|
Abstract
|
|
|
Background: Panax ginseng is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means “cure for all”. Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation.
Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extract in vitro and HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG in vivo. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin.
Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In the in vivo experiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone.
Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product.
|
|
|
KEYWORD
|
|
|
Antiaging, Human trials, Korean Red Ginseng extract, Melanogenesis, Wrinkles
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|